Lecturer Tsuruya's paper has been published in J Lipid Res. Abcb4 was knocked out using genome editing technology in human bile acid mice, and a cholestasis mouse was created, which is expected to become a model mouse for human congenital cholestasis.
Tsuruya K, Yokoyama K, Mishima Y, Ida K, Araki T, Ieda S, Ohtsuka M, Inagaki Y, Honda A, Kagawa T , Kamiya A. Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion. J Lipid Res. 2024 Sep;65(9):100616. doi: 10.1016/j.jlr.2024.100616. Epub 2024 Aug 5.PMID: 39111549
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